A cheap and widely available prescription drug can improve symptoms of irritable bowel syndrome (IBS), according to new research.
Data from a trial presented on Monday at the United European Gastroenterology meeting in Copenhagen showed that patients taking amitriptyline were almost twice as likely to report an overall improvement in symptoms as those taking a placebo.
IBS affects 5% to 10% of people worldwide, causing abdominal pain and changes to bowel movements that fluctuate in severity over time. There are treatments but no known cure.
“Patients with IBS can have impairments in quality of life of a similar magnitude to individuals with other chronic gastrointestinal conditions, such as Crohn’s disease, and worse quality of life than patients with other chronic non-gastrointestinal diseases,” researchers said in a report of the study published in The Lancet.
The 436 patients in the study had suffered with moderate to severe symptoms and an average duration of IBS of 10 years. They received either amitriptyline or a placebo along with instructions for increasing or decreasing the number of tablets they were taking depending on their symptoms.
Six months later, those taking amitriptyline reported a bigger improvement in their symptom scores and were almost twice as likely as those taking a placebo to report improvements in IBS symptoms.
Amitriptyline was originally used at high doses to treat depression but is rarely used for this purpose now because better treatments are available.
In the current study, anxiety or depression scores were not affected by the drug, suggesting that the beneficial effects of the medication took place in the gut, according to the researchers.
Doctors already prescribe the drug for chronic nerve and back pain, but they “haven’t often prescribed amitriptyline for IBS as the research evidence was uncertain,” study co-leader Hazel Everitt of the University of Southampton said in a statement. “Our new research provides good evidence of benefit.”
This newsletter was edited by Bill Berkrot. Additional reporting by Shawana Alleyne-Morris.